Autosampler Markelov HS9000

The Markelov HS 9000 static and dynamic headspace autosampler is designed with standard features such as a dual needle design and horizontal rotary mixing. Sensitivity can be increased up to 100 times as the result of the dual needle’s ability to continually sweep the headspace for concentration on the optional adsorbent trap or at the analytical column. The autosampler also has the ability to switch between static time, fixed loop injection and dynamic headspace injections within the same schedule.

Features include:

• 90 Position sample Carousel, 12 position platen
• Horizontal vial orientation exposes more of the sample to the headspace, decreasing equilibrium times
• Traditional time-controlled headspace injections
• Fixed sample loop injections
• On-column pre-concentration in single needle mode
• On-column pre-concentration in dual needle mode (patented)
• Optional trap for dual needle headspace sweep to improve sensitivity 100x (patented)
• Designed to connect to any GC platform

The HS9000 utilizes a closed sample introduction system. Unlike syringe injection system, the loss of headspace vapor during the injection process due to vapor pressure changes is never a concern. In addition to the sensitivity benefits of the Dynamic Headspace technology, the HS9000 delivers the added flexibility of performing traditional fixed loop injection and the time-based injection incorporated within a single system. Whether your preference is to make a highly reproducible timed injection to minimize the number of sample pathway components, a known fixed volume loop injection or a concentrated injection for improved sensitivity, the HS9000 is the right instrument for you.

• Static Loop Injection – A fixed volume loop available in various sizes is filled with the headspace vapor to inject a know volume of sample into the GC
• Static Time Based Injection (Pressure Balanced) – The headspace vapor is directed to the GC for a programmed period of time.
• Dynamic Headspace Trap injection – The headspace vapor is continually displaced from sample vial and collected on an adsorbent trap for a concentrated injection.
• Dynamic headspace Time Injection – The headspace vapor is continually displaced from sample vial and directed to the GC

High Temperature Capabilities. The entire sample pathway can be heated to 300C delivering unmatched application capabilities. Condensation of high boiling point compounds in the sample is minimized unlike headspace samplers with limited temperature ranges.

Secondary Trap Option. A pre-trap option can be included in the sample flow pathway to be used to selectively remove unwanted compounds before injection to the GC. In many applications, this can dramatically reduce or eliminate compounds such as water from the chromatogram.

Patented Rotary Mixing Technology. The HS9000 utilizes a patented horizontal rotary evaporation mixing technique. This unique mixing mode places the sample vials in a nearly horizontal position to expose more condensed sample to the available headspace.Since the concentration in the headspace reflects only the surface concentration of the condensed sample, by horizontally rotating the vial more surface area is exposed for a faster and more efficient evaporation, which leads to shorter equilibration times and reduces the potential of thermal breakdown. Calculations show that by cutting the thickness of the sample in half, the equilibration can be reduced by factor of four. The user also has several missing options including variable speed and an “Agitate” mode which only partially rotates the vial.

Temperature Control. Control of sample temperature is the most critical headspace method parameter to assure accurate and reproducible results. A change of 1C could change the partition coefficient (K) by as much as 10%. To maintain thermal uniformity throughout the critical equilibration and sampling process the HS9000 utilizes a unique mechanism. This feature enables the sample vial to remain in the heated platen during sampling, reducing temperature variations and improving reproducibility.

Maximum Inertness. The inert Sulfinertâ sample pathway from the sample needle to transfer line protects against sample loss and carryover, delivering superior accuracy. Even the most chemical active compounds can be analyzed without the need to change any of the sample pathways.

Applications. Whether you work is regulatory, quality control or research, the HS9000 is the ideal tool for your application.

• Pharmaceutical Analysis. Residual Solvents and other Organic Volatile Impurities are the result of the manufacturing process of drug products. In an afford to protect the health of patients, pharmaceutical manufacturing facilities must monitor the presence and concentration of the potentially harmful chemicals in accordance with the International Conference on Harmonization. The ICH regulates the daily exposure concentration limits of these solvents. As the result of newly published toxicity data, these exposure limits have been reduced over the past several years. As the trend for lower levels of detection continues, the sensitivity improvements gained from the Dynamic Headspace sampling technique make the HS9000 an invaluable tool for the Quality Control Pharmaceutical laboratory.
• Forensic Analysis. The determination of alcohol in blood is a commonly used high throughput application in the forensic laboratory. With any high throughput application, speed and carryover are the primary concerns. The inert sample pathway and the 90-position sample capacity make the HS9000 the ideal tool for any forensic application to rapidly produce accurate and defensible data.
• Polymer and Consumer Product analysis. Many different polymers are commonly used in various consumer products. The determination of residual monomer and other organic volatile components created during the polymerization process is an important quality control application. Benefits of the HS9000, such as the horizontal rotary mixing and the dynamic headspace sampling techniques, provide powerful tool to measure trace levels of residual monomers and other volatile compounds in solid matrices.